Panigoniak, who was born near Chesterfield Inlet, Nunavut, was a household name in the territory, with many considering him the father of Inuktitut music.
He had been in poor health, battling Parkinson's disease for many years, and had been living in Ottawa at the Embassy West Senior Living home.
Panigoniak was also a longtime broadcaster at CBC Radio.
In the 70's Charlie released KA MATOTC, which translates to "I miss my girlfriend" That song put him on the Indigenous Music Map throughout the North.
Panigoniak was named to the Order of Nunavut in 2012. The distinguished award honours people who have made an outstanding contribution to the cultural, social or economic well-being of the territory.
Charlie was 72.