The investigation into the matter continues.
Lethbridge police responded to the scene of what officials called a 'high-risk' incident in the community Thursday.
Officials say the situation unfolded in the 800 block of 16 Street South.
According to a release, police were executing a search warrant on a home in the area and discovered "several packages of concern."
"The Explosives Disposal Unit has been called in to ensure the safety of all," police wrote in the release."
Five people were in the home - two of them from an upstairs suite and three occupants of the basement suite were all arrested.
Shortly before 1 a.m., Lethbridge Police Service officials confirmed that the explosives disposal unit had rendered two suspicious items safe and several other suspicious items had been removed from the scene.